TRIMETHOPRIM - PMC

Ann Versporten, Robin Bruyndonckx, Niels Adriaenssens, Niel Hens, Dominique L Monnet, Geert Molenberghs, Herman Goossens, Klaus Weist, Samuel Coenen, the ESAC-Net study group

J Antimicrob Chemother. 2021 Jul; 76(Suppl 2): ii45–ii59. Published online 2021 Aug 1. doi: 10.1093/jac/dkab177

PMCID:: PMC8314111

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High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance

Morgan A. Wambaugh, Viplendra P. S. Shakya, Adam J. Lewis, Matthew A. Mulvey, Jessica C. S. Brown

PLoS Biol. 2017 Jun; 15(6): e2001644. Published online 2017 Jun 20. doi: 10.1371/journal.pbio.2001644

PMCID:: PMC5478098

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Chemical biology-whole genome engineering datasets predict new antibacterial combinations

Arthur K. Turner, Muhammad Yasir, Sarah Bastkowski, Andrea Telatin, Andrew Page, Mark Webber, Ian Charles

Microb Genom. 2021; 7(12): 000718. Published online 2021 Dec 7. doi: 10.1099/mgen.0.000718

PMCID:: PMC8767339

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Cranial neural tube defect after trimethoprim exposure

Nor Linda Abdullah, Renuka Gunasekaran, Siti Waheeda Mohd-Zin, Bee-Hui Lim, Pramila Maniam, Anis Shuhada Mohd-Salleh, Meow-Keong Thong, Zamri Chik, Noreena Nordin, Zaliha Omar, Julia Patrick Engkasan, Dharmendra Ganesan, Zakaria Nurul Aiezzah, Azlina Ahmad-Annuar, Noraishah Mydin Abdul-Aziz

BMC Res Notes. 2018; 11: 475. Published online 2018 Jul 16. doi: 10.1186/s13104-018-3593-1

PMCID:: PMC6048906

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Use of other antimicrobial drugs is associated with trimethoprim resistance in patients with urinary tract infections caused by E. coli

M. Mulder, A. Verbon, J. Lous, W. Goessens, B. H. Stricker

Eur J Clin Microbiol Infect Dis. 2019; 38(12): 2283–2290. Published online 2019 Sep 7. doi: 10.1007/s10096-019-03672-2

PMCID:: PMC6858404

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Metabolomic profiling of Burkholderia cenocepacia in synthetic cystic fibrosis sputum medium reveals nutrient environment-specific production of virulence factors

Olakunle A. Jaiyesimi, Andrew C. McAvoy, David N. Fogg, Neha Garg

Sci Rep. 2021; 11: 21419. Published online 2021 Nov 1. doi: 10.1038/s41598-021-00421-4

PMCID:: PMC8560942

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A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo

Xiaojian Wang, Clarissa A. Borges, Xinghai Ning, Mohammad Rafi, Jingtuo Zhang, Bora Park, Kiyoko Takemiya, Carlo Lo Sterzo, W. Robert Taylor, Lee Riley, Niren Murthy

Bioconjug Chem. Author manuscript; available in PMC 2018 May 23.

Published in final edited form as: Bioconjug Chem. 2018 May 16; 29(5): 1729–1735. Published online 2018 Apr 25. doi: 10.1021/acs.bioconjchem.8b00177

Correction in:: Bioconjug Chem. 2018 Oct 19

PMCID:: PMC5966298

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Oxidative Damage Blocks Thymineless Death and Trimethoprim Poisoning in Escherichia coli

T. V. Pritha Rao, Andrei Kuzminov

J Bacteriol. 2022 Jan; 204(1): e00370-21. Prepublished online 2021 Oct 11. Published online 2022 Jan 18. doi: 10.1128/JB.00370-21

PMCID:: PMC8765444

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Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine

Robert Elsby, Stephen Chidlaw, Samuel Outteridge, Sarah Pickering, Amy Radcliffe, Rebecca Sullivan, Hayley Jones, Philip Butler

Pharmacol Res Perspect. 2017 Oct; 5(5): e00357. Published online 2017 Sep 21. doi: 10.1002/prp2.357

PMCID:: PMC5625161

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The disposition of trimethoprim and sulfadiazine in neonatal foals after intravenous administration

Carl Ekstrand, Katarina Nostell, Ronette Gehring, Ulf Bondesson, Johan Bröjer

Vet Med Sci. 2022 May; 8(3): 1065–1071. Published online 2022 Feb 13. doi: 10.1002/vms3.763

PMCID:: PMC9122441

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Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

Agnieszka Wróbel, Karolina Arciszewska, Dawid Maliszewski, Danuta Drozdowska

J Antibiot (Tokyo) 2020; 73(1): 5–27. Published online 2019 Oct 2. doi: 10.1038/s41429-019-0240-6

PMCID:: PMC7102388

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Characterization of Dihydrofolate Reductase Genes from Trimethoprim-Susceptible and Trimethoprim-Resistant Strains of Enterococcus faecalis

Teresa M. Coque, Kavindra V. Singh, George M. Weinstock, Barbara E. Murray

Antimicrob Agents Chemother. 1999 Jan; 43(1): 141–147. doi: 10.1128/aac.43.1.141

PMCID:: PMC89034

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Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury

Yanshan Cao, Ahsan Bairam, Alison Jee, Ming Liu, Jack Uetrecht

Toxicol Sci. 2021 Mar; 180(1): 17–25. Published online 2021 Jan 4. doi: 10.1093/toxsci/kfaa182

PMCID:: PMC7916736

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Urinary Concentrations and Antibacterial Activities of Nitroxoline at 250 Milligrams versus Trimethoprim at 200 Milligrams against Uropathogens in Healthy Volunteers

Florian M. E. Wagenlehner, Fabian Münch, Adrian Pilatz, Birte Bärmann, Wolfgang Weidner, Christine M. Wagenlehner, Marion Straubinger, Holger Blenk, Wolfgang Pfister, Michael Kresken, Kurt G. Naber

Antimicrob Agents Chemother. 2014 Feb; 58(2): 713–721. doi: 10.1128/AAC.02147-13

PMCID:: PMC3910821

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Factors That Cause Trimethoprim Resistance in Streptococcus pyogenes

René Bergmann, Mark van der Linden, Gursharan S. Chhatwal, D. Patric Nitsche-Schmitz

Antimicrob Agents Chemother. 2014 Apr; 58(4): 2281–2288. doi: 10.1128/AAC.02282-13

PMCID:: PMC4023743

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A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug–Drug–Gene Interaction Predictions

Denise Türk, Nina Hanke, Thorsten Lehr

Pharmaceutics. 2020 Nov; 12(11): 1074. Published online 2020 Nov 10. doi: 10.3390/pharmaceutics12111074

PMCID:: PMC7696733

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Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya

Michael Green, Kephas Otieno, Abraham Katana, Laurence Slutsker, Simon Kariuki, Peter Ouma, Raquel González, Clara Menendez, Feiko ter Kuile, Meghna Desai

Malar J. 2016; 15: 7. Published online 2016 Jan 5. doi: 10.1186/s12936-015-1049-9

PMCID:: PMC4700759

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Figure 5Enzyme inhibition assay using trimethoprim (20 µg/ml) and trimethoprim susceptible S. aureus ATCC 25923.

An agar plate section containing trimethoprim (20 µg/ml), was inoculated with trimethoprim susceptible S. aureus ATCC 25923. An agar plug containing the trimethoprim inhibiting soil bacteria were placed into the inoculated trimethoprim agar. The soil bacteria producing the enzyme inhibiting trimethoprim is located in the center circle (A). The ring of growth of trimethoprim susceptible S. aureus, which has been protected from the inhibitory effects of trimethoprim by the soil bacteria enzyme (B). There is no S. aureus growth outside the zone of trimethoprim inhibition by the soil bacteria (C).

The Culturable Soil Antibiotic Resistome: A Community of Multi-Drug Resistant Bacteria

PLoS One. 2013;8(6):e65567.
Figure 3. Passing-Bablock regression of trimethoprim and sulfamethoxazole dried plasma and urine spots versus liquid plasma and urine sample concentrations (gray line represents line of unity; black line is the regression line; dashed lines represent 95% CI).

(A) Liquid plasma sample versus dried plasma spot concentrations for trimethoprim and sulfamethoxazole. (B) Liquid urine sample versus dried urine spot concentrations for trimethoprim and sulfamethoxazole.
DPS: Dried plasma spot; DUS: Dried urine spot; LPS: Liquid plasma sample; LUS: Liquid urine sample; SMX: Sulfamethoxazole; TMP: Trimethoprim.

Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots

Bioanalysis. 2015 May;7(9):1137-1149.
Figure 3

FTIR spectra of (A) trimethoprim D-aspartate, (B) trimethoprim L-aspartate and (C) trimethoprim.

Preparation and Characterization of Amino Acids-Based Trimethoprim Salts

Pharmaceutics. 2012 Mar;4(1):179-196.
Figure 4

FTIR spectra of (A) trimethoprim D-glutamate, (B) trimethoprim L-glutamate and (C) trimethoprim.

Preparation and Characterization of Amino Acids-Based Trimethoprim Salts

Pharmaceutics. 2012 Mar;4(1):179-196.